https://journals.prz.edu.pl./ctb <div align="justify"> <p><span style="color: #333333; font-family: Roboto, sans-serif;"><span style="font-size: 100%;"><strong>Chemical Technology &amp; Biotechnology</strong>, issued since 2017 r., are a continuation of research publications issued previously under the name "Scientific Journals of the Rzeszów University of Technology - Chemistry". Journal is published in <span class="VIiyi" lang="en"><span class="JLqJ4b ChMk0b C1N51c" data-language-for-alternatives="en" data-language-to-translate-into="pl" data-phrase-index="0" data-number-of-phrases="1"><span class="Q4iAWc">continuous</span></span></span> mode.<br></span></span><span style="color: #333333; font-family: Roboto, sans-serif;"><span style="font-size: 100%;">The main topics of the journal are issues related to chemistry and chemical technology, chemical engineering and biotechnology. The leading discipline is chemical engineering in the field of engineering and technology.<br></span></span><span style="color: #333333; font-family: Roboto, sans-serif;"><span style="font-size: 100%;">e-ISSN <span class="lead">2720-6793</span></span></span></p> </div> Politechnika Rzeszowska en-US Chemical Technology & Biotechnology 2720-6793 https://journals.prz.edu.pl./ctb/article/view/1619 <p>Kidney cancer (RCC) and bladder cancer (BC) are among the most frequently diagnosed cancers worldwide. They are characterized by high mortality and recurrence rates. In response to the rising incidence and mortality rates, scientists are exploring innovative diagnostic and therapeutic methods. Metabolomics, which analyzes metabolite levels, may enable early diagnosis and monitoring of therapy progress. Compared to other omics technologies, it focuses on the outcomes of metabolite activity, providing a unique perspective on processes occurring in cancer cells. Metabolomic analyses utilize techniques such as mass spectrometry. These methods allow the identification of biomarkers and precise determination of the chemical composition of biological samples. However, the most commonly used method is liquid chromatography-mass spectrometry (LC-MS), which enables the most comprehensive screening of cancer metabolomes. Recent studies show significant progress in recognizing characteristic metabolites associated with urological cancers, although this area remains partially unexplored. Research on circulating metabolites, especially in easily accessible samples like blood or urine, demonstrates promising potential in clinical practice. Study results reveal differences in metabolic profiles between various stages of cancer advancement, which may have clinical significance. The future of this field involves an increasing number of clinical cohorts, standardization of sample preparation, and further improvements in instrument sensitivity and speed. LC-MS-based metabolomics has the potential to contribute to the improvement of diagnostics, therapy, and the quality of life for patients with urological cancers. However, challenges, such as the lack of uniform methodologies and understanding of metabolite determinants, require further research and innovation.</p> Wiktoria Szuberla Maria Wrona Copyright (c) 2024 Chemical Technology & Biotechnology 2024-04-08 2024-04-08 70 75 10.7862/rc.2024.1 https://journals.prz.edu.pl./ctb/article/view/1790 <p>This paper presents the results of studies on the products of hydroxyacetone and hydroxyacetone tosylate dithioketalization with ethane-1,2-dithiol and propane-1,3-dithiol. The process was carried out in an inert gas atmosphere, argon, or in the air atmosphere and with a variable excess of one of the substrates, here the dithiol reagent. The structure elucidation and the reaction mechanism for the formation of the isolated products have been discussed. Structure products were confirmed using ¹H NMR and ¹³C NMR spectroscopy as well as mass spectrometry. The structure of one of the main products, 1,2-bis((2-methyl-1,4-dithian-2-yl)thio)ethane, was confirmed by single-crystal X-ray diffraction analysis. It was obtained with yield up to 62%. The studied dithioketalization process of selected ketones allows for the efficient synthesis of 2-methyl-1,3-dithiolan-2-yl)methanol, (2-methyl-1,3-dithian-2-yl)methanol and 3-((2-methyl-1,4-dithiepan-2-yl)thio)propane-1-thiol with yields of 63%, 66% and 50% respectively. Furthermore, we disclose an alternative synthesis of 5-methyl-2,3-dihydro-1,4-dithiine, a synthetically useful building block.</p> Dawid T. Leja Piotr A. Guńka Wiktoria Florjan Esra Erdem Grażyna Groszek Copyright (c) 2024 Chemical Technology & Biotechnology 2024-11-21 2024-11-21 76 87 10.7862/rc.2024.2